Samir Ghosheh was born in Jerusalem in 1940. He attended Jerusalem schools and obtained his secondary school education certificate from the Ar Rashidiya School. 

In the 1964/65 academic year, Ghosheh obtained a B.A. in dentistry from the Damascus University. 

Ghosheh worked in a private clinic in the city of Zarqa in Jordan. He was arrested in 1996 and after the Jarash forests had fallen in 1971. 

Ghosheh was member of the Arab Nationalists Movement and a leading activist in the Palestinian and Arab student’s movement. 

In July 1967, Ghosheh cofounded the Popular Struggle Front. In addition to providing primary incentives at its start, Ghosheh was a prominent member and secretary of the Front. 

Ghosheh was elected Secretary General of the Popular Struggle Front with a unanimous vote of members on the 1974 Conference of the Front. 

Ghosheh was appointed member on the Armed Struggle Command in 1969 and on the Palestinian Joint Command in 1970. 

Ghosheh was a member of the Palestinian National Council and PLO Central Council. 

Ghosheh exercised his national activity in Jordan, Syria and Lebanon. Following Israel’s invasion of Beirut in 1982, Ghosheh left Lebanon. He travelled to Tunis in 1989. 

On 4 August 1983, Ghosheh was married to his life’s companion Sahar ‘Am Ali. 

In January 2007, President Mahmoud Abbas appointed Ghosheh Chairman of the PLO Jerusalem Affairs Department. 

Ghosheh was elected member on the PLO Executive Committee in 1991. 

After the Palestinian National Authority had been established in 1994, Ghosheh returned to his homeland. Between 1994 and 1998, Ghosheh was the first Minister of Labour in the Palestine National Authority. 

In late 1998, Ghosheh resigned his post from the Palestinian Government. 

After Feisal al Husseini had passed away, Ghosheh was in charge of the PLO Jerusalem File and Orient House between 2002 and 2003. 

Ghosheh published many books and studies on political, organisational and social conditions. 

Ghosheh died in Amman on 3 August 2009 and was buried in the El Bireh cemetery on the next day.